Download ebook Cell Physiology Volume 32
Download ebook Cell Physiology Volume 32

Cell Physiology Volume 32.cU S Government
Cell Physiology Volume 32
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Author: U S Government
Number of Pages: 150 pages
Published Date: 14 Jan 2013
Publisher: Rarebooksclub.com
Publication Country: Miami Fl, United States
Language: English
ISBN: 9781234145095
File Name: Cell.Physiology.Volume.32.pdf
Download Link: Cell Physiology Volume 32
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This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1913 edition. Excerpt: ...as demanded by Morawitz s theory. Nor is it possible to assume that the kephalin acted as a kinase to activate alone the prothrombin present in the plasma. Other experiments, made with oxalated normal (non-peptonized) plasma, subsequently dialyzed for twenty-four hours to remove excess of oxalate, showed that the kephalin has no such action. Such plasmas clot readily on the addition of thrombin or of calcium solutions' but are entirely unaffected by solutions of kephalin. The only hypothesis that explains satisfactorily the result obtained is that the kephalin by neutralizing the antithrombin contained in the peptone plasma allowed the thrombin present to react with the fibrinogen. The specimen--lot II--allowed to stand before oxalat _ ing clotted more readily than the other specimen--lot I--because more thrombin had formed. Some subsequent experiments carried out in a manner similar to the one described above gave a different result in that the solutions of kephalin did not cause clotting in the dialyzed plasma. Investigation showed that one difficulty lay in the length of time that the oxalated plasma was submitted to dialysis. As is well known thrombin is easily adsorbed and it is, therefore, probable that in plasma in which little thrombin is present this substance may be removed partially or completely either as a result of dialyzing off or because of adsorption by the substance of the dialyzing tube. If such an action takes place kephalin of course can no longer induce coagulation, if its action is limited to neutralizing the antithrombin. In later experiments, therefore, the plasma was examined from time to time during the dialysis to determine whether oxalate was still present and whether kephalin solutions caused...

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